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162 research outcomes, page 1 of 9
  • publication . Article . 2009
    Open Access
    Authors:
    Papadopoulos, G. L.; Alexiou, P.; Maragkakis, M.; Reczko, M.; Hatzigeorgiou, A. G.;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Summary: DIANA-mirPath is a web-based computational tool developed to identify molecular pathways potentially altered by the expression of single or multiple microRNAs. The software performs an enrichment analysis of multiple microRNA target genes comparing each set of ...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Norman E. Davey; M. Madan Babu; Martin Blackledge; Alan Bridge; Salvador Capella-Gutierrez; Zsuzsanna Dosztanyi; Rachel Drysdale; Richard J. Edwards; Arne Elofsson; Isabella C. Felli; ...
    Publisher: F1000 Research Ltd

    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELI...

  • publication . Article . 2009
    Open Access English
    Authors:
    Panagiotis Alexiou; Thanasis Vergoulis; Martin Gleditzsch; George Prekas; Theodore Dalamagas; Molly Megraw; Ivo Grosse; Timos Sellis; Artemis G. Hatzigeorgiou;
    Persistent Identifiers
    Publisher: Oxford University Press

    MicroRNAs are small, non-protein coding RNA molecules known to regulate the expression of genes by binding to the 3 0 UTR region of mRNAs. MicroRNAs are produced from longer transcripts which can code for more than one mature miRNAs. miRGen 2.0 is a database that aims t...

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  • publication . Article . Other literature type . 2021
    Open Access
    Authors:
    Spyros Tastsoglou; Dimitrios Zisis; Giorgos Skoufos; Artemis G. Hatzigeorgiou; Marios Miliotis; Ioannis Kavakiotis; Athanasios Alexiou; Eleni C. Gkotsi; Anastasia Lambropoulou; Vasileios Lygnos; ...
    Persistent Identifiers
    Publisher: MDPI AG

    Simple Summary Only recently have the important biomarker capacities of microRNAs (miRNAs) in blood samples during disease been revealed. miRNAs are abundantly detected in circulation, and are less prone to degradation than longer RNA. Details regarding potential discri...

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  • publication . Article . 2016
    Closed Access
    Authors:
    Vasiliki D. Kostiou; Margarita C. Theodoropoulou; Stavros J. Hamodrakas;
    Persistent Identifiers
    Publisher: Elsevier BV

    Heterotrimeric G-proteins form a major protein family, which participates in signal transduction. They are composed of three subunits, Gα, Gβ and Gγ. The Gα subunit is further divided in four distinct families Gs, Gi/o, Gq/11 and G12/13. The goal of this work was to det...

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  • publication . Article . 2021
    Open Access
    Authors:
    Paraskevi N. Polymenakou; Paraskevi Nomikou; Haris Zafeiropoulos; Manolis Mandalakis; Thekla I. Anastasiou; Stephanos P. Kilias; Nikos C. Kyrpides; Georgios Kotoulas; Antoniοs Magoulas;
    Persistent Identifiers
    Publisher: eScholarship, University of California
    Country: United States

    Marine microbial communities are an untapped reservoir of genetic and metabolic diversity and a valuable source for the discovery of new natural products of biotechnological interest. The newly discovered hydrothermal vent field of Santorini volcanic complex located in ...

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  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Huber, Wolfgang; Carey, Vincent J; Gentleman, Robert; Anders, Simon; Carlson, Marc; Carvalho, Benilton S; Bravo, Hector Corrada; Davis, Sean; Gatto, Laurent; Girke, Thomas; ...
    Persistent Identifiers
    Country: Belgium

    Bioconductor is an open-source, open-development software project for the analysis and comprehension of high-throughput data in genomics and molecular biology. The project aims to enable interdisciplinary research, collaboration and rapid development of scientific softw...

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  • software . 2017
    Authors:
    Bagos, Pantelis;
    Publisher: bio.tools

    PRED-TAT is a tool that takes a protein sequence as input and discriminating Sec from Tat signal peptides and predicting their cleavage sites.

  • publication . Article . 2015
    Open Access English
    Authors:
    Duarte, Afonso M S; Psomopoulos, Fotis E; Blanchet, Christophe; Bonvin, Alexandre M J J; Corpas, Manuel; Franc, Alain; Jimenez, Rafael C; de Lucas, Jesus M; Nyrönen, Tommi; Sipos, Gergely; ...
    Publisher: HAL CCSD
    Countries: Netherlands, Spain, France
    Project: WT , AKA | ELIXIR - Data for Life Eu... (273655), EC | WENMR (261572), EC | BIOMEDBRIDGES (284209), FCT | EXPL/BBB-BEP/1356/2013 (EXPL/BBB-BEP/1356/2013), FCT | SFRH/BPD/78075/2011 (SFRH/BPD/78075/2011), EC | EGI-INSPIRE (261323)

    With the increasingly rapid growth of data in life sciences we are witnessing a major transition in the way research is conducted, from hypothesis-driven studies to data-driven simulations of whole systems. Such approaches necessitate the use of large-scale computationa...

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  • publication . Article . 2020
    Open Access
    Authors:
    Eva Alloza;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
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  • publication . Article . 2019 . Embargo End Date: 13 Jan 2020
    Open Access English
    Authors:
    Davey, Norman E.; Babu, M. Madan; Blackledge, Martin; Bridge, Alan; Capella-Gutierrez, Salvador; Dosztanyi, Zsuzsanna; Drysdale, Rachel; Edwards, Richard J.; Elofsson, Arne; Felli, Isabella C.; ...
    Publisher: Apollo - University of Cambridge Repository
    Countries: United Kingdom, Cyprus, Netherlands, Belgium, Spain, United Kingdom
    Project: UKRI | Bioinformatics Resources ... (BB/P024092/1), NIH | UniProt supporting an int... (3U24HG007822-05S1), EC | IDPfun (778247), WT | Protein Data Bank in Euro... (104948)

    Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELI...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Maria Vasilarou; Nikolaos Alachiotis; Joanna Garefalaki; Apostolos Beloukas; Pavlos Pavlidis;
    Persistent Identifiers
    Country: Netherlands

    Full-genome-sequence computational analyses of the SARS-coronavirus (CoV)-2 genomes allow us to understand the evolutionary events and adaptability mechanisms. We used population genetics analyses on human SARS-CoV-2 genomes available on 2 April 2020 to infer the mutati...

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  • publication . Other literature type . Article . Preprint . 2021 . Embargo End Date: 27 Jan 2022
    Open Access English
    Authors:
    Walsh I.; Fishman D.; Garcia-Gasulla D.; Titma T.; Pollastri G.; Capriotti E.; Casadio R.; Capella-Gutierrez S.; Cirillo D.; Del Conte A.; ...
    Persistent Identifiers
    Publisher: Nature Research
    Countries: Spain, Italy, Italy, Italy, Belgium

    Supervised machine learning is widely used in biology and deserves more scrutiny. We present a set of community-wide recommendations (DOME) aiming to help establish standards of supervised machine learning validation in biology. Formulated as questions, the DOME recomme...

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  • publication . Article . 2014
    Open Access
    Authors:
    Panagiotis Moulos; Pantelis Hatzis;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    RNA-Seq is gradually becoming the standard tool for transcriptomic expression studies in biological research. Although considerable progress has been recorded in the development of statistical algorithms for the detection of differentially expressed genes using RNA-Seq ...

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  • publication . Article . 2019
    Authors:
    Birgit Vogel; Giora Weisz; C. Michael Gibson; Ioannis Iakovou; Annapoorna Kini; Serdar Farhan; Sabato Sorrentino; Michela Faggioni; Antonio Colombo; Philippe Gabriel Steg; ...
    Persistent Identifiers
    Publisher: Georg Thieme Verlag KG

    Background Data on geographical variations in dual antiplatelet therapy (DAPT) cessation and the impact on outcomes after percutaneous coronary intervention (PCI) are limited. We sought to evaluate geographical patterns of DAPT cessation and associated outcomes in pati...

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  • publication . Article . 2017
    Open Access
    Authors:
    John Alexander; Dimitris Mantzaris; Marianthi Georgitsi; Petros Drineas; Peristera Paschou;
    Persistent Identifiers
    Publisher: Zenodo
    Country: United Kingdom
    Project: EC | TS-EUROTRAIN (316978), EC | EMTICS (278367)

    Background: The increasing volume and complexity of high-throughput genomic data make analysis and prioritization of variants difficult for researchers with limited bioinformatics skills. Variant Ranker allows researchers to rank identified variants and determine the mo...

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  • publication . Article . 2016
    Open Access
    Authors:
    Lakiotaki, Kleanthi; Kartsaki, Evgenia; Kanterakis, Alexandros; Katsila, Theodora; Patrinos, George P.; Potamias, George;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: WT , EC | RD-CONNECT (305444)

    One of the challenges that arise from the advent of personal genomics services is to efficiently couple individual data with state of the art Pharmacogenomics (PGx) knowledge. Existing services are limited to either providing static views of PGx variants or applying a s...

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  • software . 2017
    Authors:
    Bagos, Pantelis;
    Publisher: bio.tools

    HMM-TM is a tool that takes a protein sequence as input and predicts the transmembrane regions of alpha-helical

  • software . 2017
    SQL
    Authors:
    Kavakiotis, Ioannis;
    Publisher: bio.tools

    Pattern discovery for microsatellite genome analysis. MiGA is a user friendly programme for the detection of all microsatellite loci in genomic data.

  • software . 2017
    Open Source C#
    Authors:
    Moschonas, Nicholas; Klapa, Maria;
    Publisher: bio.tools

    PICKLE (Protein InteraCtion KnowLedgebasE) is a meta-database for the direct protein-protein interactome of the human and the mouse proteomes, integrating publicly available source protein-protein interaction (PPI) databases via genetic information ontology. PICKLE inte...

162 research outcomes, page 1 of 9